Gene

rsp-4

Species
Caenorhabditis elegans
Symbol
rsp-4
Name
SR Protein (splicing factor) 4
Synonyms
  • CELE_EEED8.7
  • CeSC35
Biotype
protein coding gene
Automated Description
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed widely. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to several human genes including SRSF2 (serine and arginine rich splicing factor 2).
WB Description
rsp-4 encodes, along with rsp-5, one of two C. elegans orthologs of the vertebrate SC35 splicing factor and member of the SR protein family of nuclear phosphoproteins that are required for constitutive splicing and influence alternative splicing regulation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23147
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
5.3876M5.3878M5.3880M5.3882M5.3884M5.3886M5.3888M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions