Version: 8.0.0
Date: Tue Jan 28 2025
scc-3
Caenorhabditis elegansWB:WBGene00004738
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

scc-3

Species
Caenorhabditis elegans
Symbol
scc-3
Name
yeast SCC (mitotic condensin subunit) homolog 3
Synonyms
  • CELE_F18E2.3
  • F18E2.3
Biotype
protein coding gene
Automated Description
Predicted to enable DNA binding activity and chromatin binding activity. Involved in meiotic sister chromatid cohesion; nuclear division; and regulation of DNA damage checkpoint. Located in chromatin and condensed chromosome. Part of cohesin complex. Is expressed in gonad. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked; Mullegama-Klein-Martinez syndrome; autosomal dominant intellectual developmental disorder 47; primary ovarian insufficiency 8; and spermatogenic failure 61. Orthologous to several human genes including STAG1 (STAG1 cohesin complex component) and STAG2 (STAG2 cohesin complex component).
WB Description
scc-3 encodes a cohesin complex subunit homologous to Saccharomyces cerevisiae Irr1p/Scc3p; SCC-3 is required during meiosis for synaptonemal complex formation and sister chromatid cohesion, proper localization of REC-8 to chromosomes, mitotic chromosome segregation, embryonic development, and vulval morphogenesis; in embryos, SCC-3 forms a cohesin complex with SCC-1, SMC-1, SMC-3, and TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS; in the germline, SCC-3 associates with chromatin of transistion zone nuclei, assembles along the longitudinal axes of synapsed chromosomes at pachytene, and unlike other cohesins, localizes throughout chromatin at diakinesis; SCC-3 localization requires TIM-1, and SCC-3 and REC-8 are mutually required for chromatin localization.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11199
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          scc-3 molecule type
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            Genetic Interactions

            scc-3 role
            scc-3 genetic perturbation
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