Version: 8.0.0
Date: Tue Jan 28 2025
slo-1
Caenorhabditis elegansWB:WBGene00004830
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

slo-1

Species
Caenorhabditis elegans
Symbol
slo-1
Name
SLOwpoke potassium channel family 1
Synonyms
  • CELE_Y51A2D.19
  • nsy-3
Biotype
protein coding gene
Automated Description
Enables calcium-activated potassium channel activity and voltage-gated potassium channel activity. Involved in several processes, including behavioral response to ethanol; nematode pharyngeal pumping; and sarcomere organization. Located in M band; striated muscle dense body; and synapse. Is expressed in several structures, including AWC; body wall musculature; non-striated muscle; pharyngeal neurons; and somatic nervous system. Used to study Duchenne muscular dystrophy and alcohol use disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; idiopathic generalized epilepsy; paroxysmal nonkinesigenic dyskinesia 3; and spermatogenic failure 79. Orthologous to several human genes including KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).
WB Description
slo-1 encodes a voltage- and calcium-activated potassium (BK) channel; SLO-1 activity is required for muscle inactivation: mutants have wild-type levels of motor activity, but have less smooth movement and tend to stop and reverse direction; SLO-1 is expressed in neurons and in body wall and vulval muscle; SLO-1 localization in proximity to the EGL-19 L-type calcium channel in muscle membrane is mediated by the dystrophin-associated protein complex (DAPC) and the ISLO-1 adapter protein with which SLO-1 physically interacts and also colocalizes with in muscle membrane.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10027
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          slo-1 molecule type
          Interactor gene
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            Genetic Interactions

            slo-1 role
            slo-1 genetic perturbation
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