Version: 8.0.0Date: Tue Jan 28 2025
Gene
smf-1
- Species
- Caenorhabditis elegans
- Symbol
- smf-1
- Name
- yeast SMF (divalent cation transporter) homolog 1
- Synonyms
- CELE_K11G12.4
- K11G12.4
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable cadmium ion transmembrane transporter activity; iron ion transmembrane transporter activity; and manganese ion transmembrane transporter activity. Involved in several processes, including manganese ion homeostasis; negative regulation of cellular response to manganese ion; and response to manganese ion. Located in apical plasma membrane. Is expressed in several structures, including hermaphrodite gonad; hypodermis; intestine; nerve ring; and neurons. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2).
- WB Description
- smf-1 encodes one of three C. elegans divalent-metal ion transporters (DMTs) orthologous to the mammalian DMT1 transporters and Saccharomyces cerevisiae Smf proteins; in C. elegans, SMF-1 plays a minor role in manganese uptake, although mutations in smf-1 do display an increased tolerance to manganese exposure; SMF-1 is broadly expressed fromlate embryogenesis through adulthood, with strongest expression seen in the intestine and its associated gland cells; in epithelia, SMF-1 displays partially overlapping localization at the apical plasma membrane with SMF-3; smf-1 transcription is regulated in response to manganese; when expressed in Saccharomyces cerevisiae, smf-1 can rescue the EGTA hypersensitivity of Smf1+2 mutants.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11706
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrX:6719669...6723066 - (3.40 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.