Gene

smf-2

Species
Caenorhabditis elegans
Symbol
smf-2
Name
yeast SMF (divalent cation transporter) homolog 2
Synonyms
  • CELE_K11G12.3
  • K11G12.3
Biotype
protein coding gene
Automated Description
Predicted to enable cadmium ion transmembrane transporter activity; iron ion transmembrane transporter activity; and manganese ion transmembrane transporter activity. Involved in intracellular iron ion homeostasis; manganese ion homeostasis; and response to manganese ion. Located in apical plasma membrane. Is expressed in dopaminergic neurons; gonadal sheath cell; marginal cell; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2).
WB Description
smf-2 encodes one of three C. elegans divalent-metal ion transporters (DMTs) orthologous to the mammalian DMT1 transporters and Saccharomyces cerevisiae Smf proteins; in C. elegans, SMF-2 appears to function as both a manganese and iron transporter that regulates metal content; mutations in smf-2 display a decreased tolerance to manganeseexposure; SMF-2 is expressed mainly in the marginal pharyngeal epithelium from late embryogenesis through adulthood; SMF-2 localizes primarily to cytoplasmic compartments, with some apical plasma membrane localization seen in the mc cells; smf-2 is overexpressed in smf-1 and smf-3 mutants, and SMF-2 appears to be required for smf-1 and smf-3 expression changes in response to manganese; when expressed in Saccharomyces cerevisiae, smf-2 can rescue the EGTA hypersensitivity of Smf1+2 mutants.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11706
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
6.7162M6.7164M6.7166M6.7168M6.7170M6.7172M6.7174M6.7176M6.7178M6.7180M6.7182M6.7184M6.7186M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions