Version: 8.0.0
Date: Tue Jan 28 2025
smo-1
Caenorhabditis elegansWB:WBGene00004888
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

smo-1

Species
Caenorhabditis elegans
Symbol
smo-1
Name
SUMO (ubiquitin-related) homolog 1
Synonyms
  • CELE_K12C11.2
  • K12C11.2
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity. Involved in several processes, including chromosome organization; multicellular organismal locomotion; and muscle cell cellular homeostasis. Predicted to be located in chromosome; cytoplasm; and microtubule cytoskeleton. Predicted to be active in nucleus. Predicted to colocalize with PML body. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; hypodermis; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in orofacial cleft 10. Orthologous to several human genes including SUMO1P1 (SUMO1 pseudogene 1).
WB Description
smo-1 encodes the C. elegans ortholog of SUMO, a small ubiquitin-like moiety that, when attached to protein substrates, regulates their subcellular localization and activity; smo-1 is an essential gene: loss of its activity results in embryonic and larval lethality; in addition, smo-1 mutants have defects in synaptonemal complex disassembly and bivalent formation, enhance meiotic defects of zhp-3::gfp mutants and show mislocalization of ZHP-3 in late pachytene; smo-1 is also required for reproductive system development, where its target may be the LIN-11 LIM homeodomain protein.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10562
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          smo-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            smo-1 role
            smo-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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