Version: 8.0.0
Date: Tue Jan 28 2025
snf-11
Caenorhabditis elegansWB:WBGene00004910
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

snf-11

Species
Caenorhabditis elegans
Symbol
snf-11
Name
Sodium: Neurotransmitter symporter Family 11
Synonyms
  • CELE_T03F7.1
  • gat-1
Biotype
protein coding gene
Automated Description
Enables gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in gamma-aminobutyric acid transport. Located in neuron projection and neuronal cell body. Is expressed in body wall musculature; enteric muscle; head mesodermal cell; nervous system; and uterine muscle. Human ortholog(s) of this gene implicated in alcohol dependence and myoclonic-atonic epilepsy. Orthologous to human SLC6A1 (solute carrier family 6 member 1).
WB Description
snf-11 encodes an electrogenic, Na[+]/Cl[-]-coupled, high-affinity GABA transporter that is required in vivo for GABA uptake, and for normal aldicarb sensitivity; SNF-11 is orthologous to human SLC6A1 (OMIM:137165); SNF-11 is selective for GABA with a Kt of ~15 microM, has an EC50 value of 168 microM, is blocked by GAT1 inhibitor SKF89976A, and has a 2:1:1 stoichiometry of Na[+]:Cl[-]:GABA; SNF-11 is expressed in several GABAergic neurons, in some other non-GABAergic neurons of the head and retrovesicular ganglion (e.g., RID), and in muscle cells; snf-11(ok156) null mutants fail to show GABA uptake in at least some GABAergic cells, and in cell culture; snf-11(ok156) mutants exhibit GABA-dependent aldicarb resistance, and show abnormal head foraging and defecation in a genetically sensitized background (GABA-transport dependent, with an unc-25 null allele); while unsensitized snf-11(ok156) mutants have grossly normal phenotype, cell cultures from snf-11(ok156) embryos completely lack normal GABA uptake.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11616
No data available
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            11.3055M11.3060M11.3065M11.3070M11.3075M11.3080M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            snf-11 molecule type
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              Genetic Interactions

              snf-11 role
              snf-11 genetic perturbation
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