Version: 8.0.0
Date: Tue Jan 28 2025
sod-1
Caenorhabditis elegansWB:WBGene00004930
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

sod-1

Species
Caenorhabditis elegans
Symbol
sod-1
Name
SOD (superoxide dismutase) 1
Synonyms
  • C15F1.7
  • CELE_C15F1.7
Biotype
protein coding gene
Automated Description
Enables copper ion binding activity; protein homodimerization activity; and superoxide dismutase activity. Involved in regulation of brood size; regulation of vulval development; and removal of superoxide radicals. Located in cytosol and mitochondrion. Is expressed in several structures, including somatic gonad and somatic nervous system. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including SOD1 (superoxide dismutase 1).
WB Description
sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10003
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            6.9728M6.9730M6.9732M6.9734M6.9736M6.9738M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            sod-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              sod-1 role
              sod-1 genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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