Version: 8.0.0
Date: Tue Jan 28 2025
spp-8
Caenorhabditis elegansWB:WBGene00004993
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

spp-8

Species
Caenorhabditis elegans
Symbol
spp-8
Name
SaPosin-like Protein family 8
Synonyms
  • C28C12.5
  • CELE_C28C12.5
Biotype
protein coding gene
Automated Description
Predicted to be active in extracellular space. Is expressed in intestine. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency; combined saposin deficiency; and late onset Parkinson's disease. Orthologous to human PSAP (prosaposin).
WB Description
Enriched in distal tip cell; germ line; intestine; and mechanosensory neurons based on SAGE; microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including hyl-2; nuo-6; and cua-1 based on microarray and RNA-seq studies. Is affected by twenty-four chemicals including 1-methylnicotinamide; mianserin; and D-glucose based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency; combined saposin deficiency; and late onset Parkinson's disease. Is predicted to encode a protein with the following domains: Sphingolipid Activators and Surfactant Proteins; Saposin B type, region 2; Saposin-like type B, region 2; Saposin-like; and Saposin B type domain. Is an ortholog of human PSAP (prosaposin). Human PSAP enables several functions, including ganglioside binding activity; protein homodimerization activity; and scaffold protein binding activity.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11480
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            8.4818M8.4820M8.4822M8.4824M8.4826M8.4828M8.4830M8.4832M8.4834M8.4836M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            spp-8 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              spp-8 role
              spp-8 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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