Version: 8.0.0Date: Tue Jan 28 2025
Gene
srf-3
- Species
- Caenorhabditis elegans
- Symbol
- srf-3
- Name
- SuRFace antigenicity abnormal 3
- Synonyms
- CELE_M02B1.1
- M02B1.1
- Biotype
- protein coding gene
- Automated Description
- Enables UDP-N-acetylglucosamine transmembrane transporter activity and UDP-galactose transmembrane transporter activity. Involved in UDP-N-acetylglucosamine transmembrane transport and UDP-galactose transmembrane transport. Located in Golgi membrane and perinuclear region of cytoplasm. Is expressed in pharyngeal gland cell; seam cell; spermatheca; and vas deferens. Used to study bacterial infectious disease. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIm. Orthologous to human SLC35A2 (solute carrier family 35 member A2).
- WB Description
- srf-3 encodes a nucleotide sugar transporter (NST) most similar to the subfamily of UDP-galactose and UDP-N-acetylgalactosamine transporters; SRF-3 can function as a nucleotide sugar transporter in heterologous in vitro and in vivo systems using UDP-galactose and UDP-N-acetylglucosamine as substrates; mutations in srf-3 alter the surface antigenicity of the cuticle in C. elegans; srf-3 mutations show altered binding to antibodies raised against the cuticles of wild-type worms, and lectins like wheat germ agglutinin; srf-3 mutants are resistant to infection by the nematode-specific pathogen, Microbacterium nematophilum, and to the adherence of bacteria like Yersinia pseudotuberculosis which form biofilms; this resistance is most likely due to an altered glycoconjugate surface composition; srf-3 mutants also show an altered response in the form of increased susceptibility to nematophagous fungi; srf-3 mutants seem to have fragile cuticles compared to wild-type; srf-3 is expressed in seam cells, glandular cells g1/g2 and the spermatheca.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10231
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrIV:12849510...12854408 + (4.90 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.