Version: 8.0.0
Date: Tue Jan 28 2025
pak-2
Caenorhabditis elegansWB:WBGene00006443
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pak-2

Species
Caenorhabditis elegans
Symbol
pak-2
Name
P21-Activated Kinase family 2
Synonyms
  • C45B11.1
  • CELE_C45B11.1
Biotype
protein coding gene
Automated Description
Predicted to enable protein serine/threonine kinase activity. Involved in nematode larval development. Predicted to be active in cytoplasm. Is expressed in hypodermis; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK4 (p21 (RAC1) activated kinase 4).
WB Description
pak-2 encodes, by alternative splicing, at least two isoforms of aputative p21-activated kinase, orthologous to Drosophila melanogasterMUSHROOM BODIES TINY; pak-2 is expressed in pharynx, thepharyngeal-intestinal valve, vulva, and spermatheca; pak-2(ok332), aprobable null allele, has no obvious mutant phenotype in isolation andhas no effect on the axonal guidance phenotype of max-2(cy2), but showssome embryonic defects and L1 lethality as a double mutant with the nullpak-1(ok448).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48015
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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        Experimental condition
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          pak-2 molecule type
          Interactor gene
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          Interactor molecule type
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            Genetic Interactions

            pak-2 role
            pak-2 genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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