Version: 8.0.0Date: Tue Jan 28 2025
Gene
tfg-1
- Species
- Caenorhabditis elegans
- Symbol
- tfg-1
- Name
- human TFG related 1
- Synonyms
- CELE_Y63D3A.5
- Y63D3A.5
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable identical protein binding activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; maintenance of protein localization in organelle; and protein secretion. Located in endoplasmic reticulum exit site and mitochondrion. Is expressed in germ line; hypodermis; intestine; and muscle cell. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Orthologous to human TFG (trafficking from ER to golgi regulator).
- WB Description
- tfg-1 encodes a tumor suppressor gene homologous to human TRK-fused gene (TFG)(OMIM: 602498); TFG-1 is sufficient and necessary to inhibit the normal apoptotic pathway; TFG-1 influences body size and responsible for determining the size of adults; TFG-1 functions in a novel pathway independent of TGF-beta; and insulin signaling to control cell growth and size; TFG-1 directly interacts with SEC-16 and controls COPII subunit accumulation at the endoplasmic reticulum exit sites; TFG-1 requires SEC-16 for its localization and SEC-16 requires TFG-1 to accumulate normally on endoplasmic reticulum exit sites; TFG-1 hexamers facilitates normal assembly of large complexes containing SEC-16 and COPII subunits; TFG-1 depletion leads to a defect in normal Golgi assembly; analogously to C. elegans TFG-1, human TFG functions at endoplasmic reticulum exit sites; TFG-1 is detectable as early as the two cell stage of embryogenesis and expression continues throughout embryogenesis, punctated pattern in cytoplasm colocalizing with mitochondrial COX1.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR15335
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrI:14101322...14104470 + (3.15 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.