Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including gonadal sheath cell; intestine; nervous system; pharynx; and tail. Orthologous to several human genes including KCNK10 (potassium two pore domain channel subfamily K member 10); KCNK16 (potassium two pore domain channel subfamily K member 16); and KCNK17 (potassium two pore domain channel subfamily K member 17).
WB Description
twk-6 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-6 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-6 in C. elegans development and/or behavior is not yet known; TWK-6 may, however, function redundantly with other TWK channels; TWK-6 is expressed in the hypodermis.