Version: 8.0.0
Date: Tue Jan 28 2025
ubc-3
Caenorhabditis elegansWB:WBGene00006702
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ubc-3

Species
Caenorhabditis elegans
Symbol
ubc-3
Name
UBiquitin Conjugating enzyme 3
Synonyms
  • CELE_Y71G12B.15
  • Y71G12B.15
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Is expressed in body wall musculature; nervous system; pharynx; and seam cell. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme) and UBE2R2 (ubiquitin conjugating enzyme E2 R2).
WB Description
ubc-3 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae and human CDC34 (OMIM:603731) which are involved in regulating protein stability during G1 and G2 cell cycle phase transitions; by homology, UBC-3 is likely required for covalent attachment of ubiquitin to select target proteins to facilitate their degradation; however, as loss of UBC-3 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UBC-3 in C. elegans development and/or behavior is not yet known.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24067
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          ubc-3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            ubc-3 role
            ubc-3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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