Enables protein kinase binding activity and scaffold protein binding activity. Involved in regulation of protein localization and synaptic vesicle localization. Located in neuron projection. Is expressed in several structures, including hypodermis; intestine; motor neurons; muscle cell; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 61. Orthologous to human RUSC1 (RUN and SH3 domain containing 1) and RUSC2 (RUN and SH3 domain containing 2).
WB Description
unc-14 encodes a RUN (RPIP8, UNC-14, and NESCA) domain-containing protein; unc-14 activity is required for axonogenesis (neurite outgrowth and axonal transport) and sex myoblast migration; in regulating axon guidance, UNC-14 functions together with the UNC-51 kinase, which binds and phosphorylates UNC-14, to properly localize the UNC-5 netrin receptor; UNC-14 also interacts with the kinesin light chain KLC-2 and thus appears to function as an adaptor protein that mediates kinesin-1-dependent transport of synaptic vesicle components; an UNC-14::GFP reporter fusion is expressed in neurons, including the VD and DD motor neurons, where it localizes to puncta in the axons or cell bodies; UNC-14 localization is dependent upon kinesin-1 (UNC-116 and KLC-2).