Gene

unc-14

Species
Caenorhabditis elegans
Symbol
unc-14
Name
UNCoordinated 14
Synonyms
  • CELE_K10D3.2
  • K10D3.2
Biotype
protein coding gene
Automated Description
Enables protein kinase binding activity and scaffold protein binding activity. Involved in regulation of protein localization and synaptic vesicle localization. Located in neuron projection. Is expressed in several structures, including hypodermis; intestine; motor neurons; muscle cell; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 61. Orthologous to human RUSC1 (RUN and SH3 domain containing 1) and RUSC2 (RUN and SH3 domain containing 2).
WB Description
unc-14 encodes a RUN (RPIP8, UNC-14, and NESCA) domain-containing protein; unc-14 activity is required for axonogenesis (neurite outgrowth and axonal transport) and sex myoblast migration; in regulating axon guidance, UNC-14 functions together with the UNC-51 kinase, which binds and phosphorylates UNC-14, to properly localize the UNC-5 netrin receptor; UNC-14 also interacts with the kinesin light chain KLC-2 and thus appears to function as an adaptor protein that mediates kinesin-1-dependent transport of synaptic vesicle components; an UNC-14::GFP reporter fusion is expressed in neurons, including the VD and DD motor neurons, where it localizes to puncta in the axons or cell bodies; UNC-14 localization is dependent upon kinesin-1 (UNC-116 and KLC-2).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15591
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
7.1230M7.1235M7.1240M7.1245M7.1250M7.1255M7.1260M7.1265M7.1270M7.1275M7.1280M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions