Version: 8.0.0
Date: Tue Jan 28 2025
unc-39
Caenorhabditis elegansWB:WBGene00006775
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

unc-39

Species
Caenorhabditis elegans
Symbol
unc-39
Name
UNCoordinated 39
Synonyms
  • ceh-35
  • CELE_F56A12.1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; generation of neurons; and mesodermal cell migration. Located in nucleus. Is expressed in several structures, including M cell; coelomocyte; neuroblasts; neurons; and somatic gonad precursor. Used to study branchiootorenal syndrome and myotonic dystrophy type 1. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Orthologous to human SIX4 (SIX homeobox 4) and SIX5 (SIX homeobox 5).
WB Description
unc-39 encodes a homeodomain transcription factor that belongs to the Six4/5 family of homeodomain proteins that includes human Six5; UNC-39 is required for axonal pathfinding in anterior-derived neurons and for specification of most mesodermal cell types and may regulate a developmental decision between migration and differentiation; UNC-39 is expressed in the embryo in anterior neurons, posteriorly derived mesoderm (somatic gonad, M mesoblast, and possibly the coelomocytes and muIntR), the CAN neurons, and body wall muscle.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10390
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            14.3735M14.3740M14.3745M14.3750M14.3755M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            unc-39 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              unc-39 role
              unc-39 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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