Gene

unc-104

Species
Caenorhabditis elegans
Symbol
unc-104
Name
UNCoordinated 104
Synonyms
  • C52E12.2
  • CELE_C52E12.2
Biotype
protein coding gene
Automated Description
Enables cytoskeletal protein binding activity; phosphatidylinositol phosphate binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including chemical synaptic transmission; positive regulation of cellular component organization; and regulation of intracellular transport. Located in several cellular components, including dendrite; neuronal cell body; and presynapse. Is expressed in epithelial cell; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2A1; NESCAV syndrome; carcinoma (multiple); hereditary sensory neuropathy (multiple); and hereditary spastic paraplegia (multiple). Orthologous to several human genes including KIF1A (kinesin family member 1A).
WB Description
unc-104 encodes a kinesin-like motor protein homologous to human axonal transporter of synaptic vesicles (ATSV, OMIM: 601255); UNC-104 is required for anterograde axonal transport of synaptic vesicles as well as differentiation of pre- and postsynaptic domains at inhibitory neuromuscular junctions; UNC-104 is expressed solely in neurons; UNC-104 retrograde movement is regulated by PTL-1/Tau, with which it physically interacts in vivo.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24115
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            6.996M6.998M7.000M7.002M7.004M7.006M7.008M7.010M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            unc-104 molecule type
            Interactor gene
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              Genetic Interactions

              unc-104 role
              unc-104 genetic perturbation
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