Version: 8.0.0Date: Tue Jan 28 2025
Gene
vab-3
- Species
- Caenorhabditis elegans
- Symbol
- vab-3
- Name
- Variable ABnormal morphology 3
- Synonyms
- CELE_F14F3.1
- F14F3.1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including male anatomical structure morphogenesis; negative regulation of distal tip cell migration; and positive regulation of glial cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including B.a; distal tip cell; head muscle; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6).
- WB Description
- vab-3 encodes a homeodomain protein that is the C. elegans Pax-6 orthologue; during development, vab-3 activity is required for proper patterning of anterior (head) hypodermal cells; vab-3 effects head development, in part, through positively regulating transcription of ceh-32, a Six/sine oculis class homeobox gene coexpressed with vab-3 in head hypodermis; vab-3 is also required for epidermal morphogenesis, epidermal cell fates, gonad cell migration and the development of sensory structures in the male tail; multiple genetic pathways including the Wnt signalling pathway and the homeobox gene, egl-5, regulate the expression of vab-3.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR45636
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrX:10499890...10519580 + (19.69 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.