Gene

zen-4

Species
Caenorhabditis elegans
Symbol
zen-4
Name
Zygotic epidermal ENclosure defective 4
Synonyms
  • CELE_M03D4.1
  • klp-9
Biotype
protein coding gene
Automated Description
Enables several functions, including identical protein binding activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including nuclear division; pronuclear migration; and regulation of actomyosin contractile ring contraction. Located in cleavage furrow; microtubule cytoskeleton; and midbody. Part of centralspindlin complex. Is expressed in germ cell and gonad. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IIIa. Orthologous to human KIF23 (kinesin family member 23).
WB Description
zen-4 encodes a kinesin-like protein that is a member of the kinesin-6 subfamily of plus-end-directed microtubule motors; loss-of-function mutations and RNAi experiments indicate that ZEN-4 is required for polar body extrusion after meiotic divisions, for completion of cytokinesis after mitosis, and for formation and/or maintenance of spindle midzone microtubules; in addition, zen-4 functions together with cyk-1 to regulate pronuclear migration; during mitosis, ZEN-4 is detected at the spindle midzone where it co-localizes with spindle microtubules, and ZEN-4 persists at the midbody remnant once cell division is complete; ZEN-4 is also occasionally seen at centrosomes in interphase cells; initial localization of ZEN-4 to the spindle midzone requires activity of the Aurora-related kinase AIR-2 which physically interacts with ZEN-4 in vitro.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24115
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            6.1185M6.1190M6.1195M6.1200M6.1205M6.1210M6.1215M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            zen-4 molecule type
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              Genetic Interactions

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