Version: 8.0.0
Date: Tue Jan 28 2025
C11E4.6
Caenorhabditis elegansWB:WBGene00007520
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

C11E4.6

Species
Caenorhabditis elegans
Symbol
C11E4.6
Name
ANK_REP_REGION domain-containing protein
Synonyms
  • CELE_C11E4.6
Biotype
protein coding gene
Automated Description
Is expressed in neurons. Orthologous to human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A) and ANKS1B (ankyrin repeat and sterile alpha motif domain containing 1B).
WB Description
Enriched in several structures, including anterior ganglion (post); dorso-rectal ganglion; head mesodermal cell; neurons; and pm8 based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; qui-1; and cua-1 based on microarray; RNA-seq; and proteomic studies. Is affected by eleven chemicals including stavudine; Zidovudine; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Sterile alpha motif domain; Ankyrin repeat; Phosphotyrosine interaction domain (PTB/PID); PTB/PI domain; Sterile alpha motif/pointed domain superfamily; Ankyrin repeat-containing domain superfamily; SAM domain (Sterile alpha motif); Ankyrin repeat and SAM domain-containing protein 1/Caskin; Ankyrin repeats (3 copies); PH-like domain superfamily; and Phosphorylation site. Is an ortholog of human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A) and ANKS1B (ankyrin repeat and sterile alpha motif domain containing 1B). Human Anks1b enables ephrin receptor binding activity.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24159
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          C11E4.6 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            C11E4.6 role
            C11E4.6 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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