Version: 8.0.0
Date: Tue Jan 28 2025
lron-5
Caenorhabditis elegansWB:WBGene00008656
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

lron-5

Species
Caenorhabditis elegans
Symbol
lron-5
Name
eLRR (extracellular Leucine-Rich Repeat) ONly 5
Synonyms
  • CELE_F10F2.4
  • F10F2.4
Biotype
protein coding gene
Automated Description
Predicted to be involved in cell development. Predicted to be located in membrane. Is expressed in intestine; nervous system; and tail. Human ortholog(s) of this gene implicated in artery disease (multiple); corneal disease (multiple); and pancreatic cancer. Orthologous to several human genes including FMOD (fibromodulin); KERA (keratocan); and LUM (lumican).
WB Description
Predicted to be involved in cell development. Predicted to be located in membrane. Expressed in nerve ring; tail; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); corneal disease (multiple); and periodontal disease (multiple). Is an ortholog of several human genes including FMOD (fibromodulin); LUM (lumican); and OMD (osteomodulin).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45617
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          lron-5 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            lron-5 role
            lron-5 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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