Version: 8.0.0
Date: Tue Jan 28 2025
ser-5
Caenorhabditis elegansWB:WBGene00008890
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ser-5

Species
Caenorhabditis elegans
Symbol
ser-5
Name
SERotonin/octopamine receptor family 5
Synonyms
  • CELE_F16D3.7
  • F16D3.7
Biotype
protein coding gene
Automated Description
Predicted to enable alpha1-adrenergic receptor activity. Involved in several processes, including nematode pharyngeal pumping; positive regulation of egg-laying behavior; and serotonin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in body wall musculature; egg-laying apparatus; intestine; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; heroin dependence; and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A) and ADRA1B (adrenoceptor alpha 1B).
WB Description
ser-5 encodes a biogenic amine receptor that is most closely related to mammalian serotonin/5-HT-6 receptors; SER-5 functions in the ASH chemosensory neurons to coordinate sensory input and locomotory behavior and in muscles to regulate serotonin's effects on egg laying; heterologously expressed ser-5 has no effect on adenylate cyclase signaling; ser-5 reporter fusions are expressed in vulval and bodywall muscles and head neurons, including ASH and AWB.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24248
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          ser-5 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            ser-5 role
            ser-5 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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