Version: 8.0.0Date: Tue Jan 28 2025
Gene
abts-1
- Species
- Caenorhabditis elegans
- Symbol
- abts-1
- Name
- Anion/Bicarbonate TranSporter family 1
- Synonyms
- CELE_F52B5.1
- F52B5.1
- Biotype
- protein coding gene
- Automated Description
- Enables chloride transmembrane transporter activity and solute:inorganic anion antiporter activity. Involved in several processes, including cholinergic synaptic transmission; regulation of GABAergic synaptic transmission; and response to serotonin. Predicted to be located in basolateral plasma membrane; lateral plasma membrane; and synapse. Predicted to be active in plasma membrane. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to several human genes including SLC4A10 (solute carrier family 4 member 10); SLC4A7 (solute carrier family 4 member 7); and SLC4A8 (solute carrier family 4 member 8).
- WB Description
- abts-1 encodes a sodium-driven chloride-bicarbonate transporter; when expressed in Xenopus oocytes, ABTS-1 exhibits robust chloride transport, as well as chloride/bicarbonate exchange activity; abts-1 responds to arsenite in the environment with an increase in mRNA levels and is required for protection against toxicity of arsenite; abts-1 is involved in cholinergic signaling as abts-1 mutant worms are hypersensitive to the paralytic effects of the cholinesterase inhibitor, aldicarb, and the nicotinic acetylcholine receptor agonist, levamisole, and arsenite enhances both these sensitivities, indicating the neuronal effects of arsenite and abts-1; abts-1 also functions partially redundantly with the potassium chloride co-transporter kcc-2, to mediate inhibitory GABA signaling in the HSNs (hermaphrodite-specific neurons) that control egg-laying, and in body wall muscles that control body length and movement; abts-1 promoter gfp fusions are expressed primarily in neurons and hypodermis, with weak fluorescence also seen in the pharynx and body wall muscle cells.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11453
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrI:8296917...8307566 - (10.65 kb)
- Assembly version
- WBcel235
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Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.