Gene

abts-1

Species
Caenorhabditis elegans
Symbol
abts-1
Name
Anion/Bicarbonate TranSporter family 1
Synonyms
  • CELE_F52B5.1
  • F52B5.1
Biotype
protein coding gene
Automated Description
Enables chloride transmembrane transporter activity and solute:inorganic anion antiporter activity. Involved in several processes, including cholinergic synaptic transmission; regulation of GABAergic synaptic transmission; and response to serotonin. Predicted to be located in basolateral plasma membrane; lateral plasma membrane; and synapse. Predicted to be active in plasma membrane. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to several human genes including SLC4A10 (solute carrier family 4 member 10); SLC4A7 (solute carrier family 4 member 7); and SLC4A8 (solute carrier family 4 member 8).
WB Description
abts-1 encodes a sodium-driven chloride-bicarbonate transporter; when expressed in Xenopus oocytes, ABTS-1 exhibits robust chloride transport, as well as chloride/bicarbonate exchange activity; abts-1 responds to arsenite in the environment with an increase in mRNA levels and is required for protection against toxicity of arsenite; abts-1 is involved in cholinergic signaling as abts-1 mutant worms are hypersensitive to the paralytic effects of the cholinesterase inhibitor, aldicarb, and the nicotinic acetylcholine receptor agonist, levamisole, and arsenite enhances both these sensitivities, indicating the neuronal effects of arsenite and abts-1; abts-1 also functions partially redundantly with the potassium chloride co-transporter kcc-2, to mediate inhibitory GABA signaling in the HSNs (hermaphrodite-specific neurons) that control egg-laying, and in body wall muscles that control body length and movement; abts-1 promoter gfp fusions are expressed primarily in neurons and hypodermis, with weak fluorescence also seen in the pharynx and body wall muscle cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11453
No data available
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            8.297M8.298M8.299M8.300M8.301M8.302M8.303M8.304M8.305M8.306M8.307M

            Sequence Details

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            Expression

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            Molecular Interactions

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              Genetic Interactions

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