Gene

sta-2

Species
Caenorhabditis elegans
Symbol
sta-2
Name
STAT transcription factor family 2
Synonyms
  • CELE_F58E6.1
  • F58E6.1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to fungus; positive regulation of antifungal peptide production; and response to wounding. Located in several cellular components, including apical part of cell; endocytic vesicle; and hemidesmosome. Part of hemidesmosome associated protein complex. Is expressed in hypodermis; interfacial epithelial cell; intestine; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); reproductive organ cancer (multiple); and scleroderma (multiple). Orthologous to several human genes including STAT1 (signal transducer and activator of transcription 1); STAT3 (signal transducer and activator of transcription 3); and STAT4 (signal transducer and activator of transcription 4).
WB Description
sta-2 encodes a member of the STAT family of transcription factors; STA-2 functions cell autonomously together with the SNF-12 sodium-dependent neurotransmitter symporter to regulate expression of antimicrobial peptides in the epidermis following fungal infection and physical wounding; STA-2 physically interacts with SNF-12; a sta-2 reporter gene is expressed in the epidermis throughout development and in the seam cells, intestine, phasmid socket cells, excretory duct cell, vulval cells and the dorsal rectal cells; STA-2 localizes to both the nucleus and the cytoplasm; in the epidermal cytoplasm, STA-2 colocalizes with SNF-12 in endocytic-like vesicles near the apical cell surface.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11801
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            9.7415M9.7420M9.7425M9.7430M9.7435M9.7440M

            Sequence Details

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            Expression

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            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            sta-2 molecule type
            Interactor gene
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              Genetic Interactions

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