Version: 8.0.0
Date: Tue Jan 28 2025
aipl-1
Caenorhabditis elegansWB:WBGene00010685
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

aipl-1

Species
Caenorhabditis elegans
Symbol
aipl-1
Name
AIP1 (Actin Interacting Protein 1) Like 1
Synonyms
  • CELE_K08F9.2
  • K08F9.2
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity. Involved in actin filament organization and regulation of protein localization. Predicted to be active in cortical actin cytoskeleton. Is expressed in body wall musculature; intestine; neurons; and spermatheca. Orthologous to human WDR1 (WD repeat domain 1).
WB Description
aipl-1 encodes a conserved WD-repeat protein that cooperates with ADF/cofilin and is highly homologous to AIP-1; the sequence of the encoded protein is 66% identical to UNC-78; aipl-1 and unc-78 have redundant and overlapping functions in organized assembly of actin filaments in embryonic muscle and the unc-78 and aipl-1 double mutant is embryonic lethal; both AIPL-1 isoforms preferentially cooperate with UNC-60B, a muscle-specific ADF/cofilin for actin filament disassembly in embryonic muscle; AIPL-1 affects localization of only F-actin-bound UNC-60B; AIPL-1 is expressed in the embryonic neurons, the intestine and the body wall muscle, in adult spermatheca and body wall muscles; AIPL-1 majorly functions in early embryonic muscle and can compensate for the function of UNC-78 in the body wall muscle.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19856
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            15.1345M15.1350M15.1355M15.1360M15.1365M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            aipl-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              aipl-1 role
              aipl-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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