Version: 8.0.0
Date: Tue Jan 28 2025
sbt-1
Caenorhabditis elegansWB:WBGene00011392
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

sbt-1

Species
Caenorhabditis elegans
Symbol
sbt-1
Name
Seven B Two (mammalian 7BT prohormone convertase chaperone) homolog 1
Synonyms
  • CELE_T03D8.3
  • T03D8.3
Biotype
protein coding gene
Automated Description
Enables peptidase activator activity and peptidase inhibitor activity. Involved in regulation of muscle contraction. Predicted to be located in extracellular region and secretory granule. Is expressed in neurons and pharynx. Orthologous to human SCG5 (secretogranin V).
WB Description
sbt-1 encodes the C. elegans ortholog of the neuroendocrine chaperone 7B2; by homology, SBT-1 is predicted to function in the maturation/activation of the EGL-3/PC2 proprotein convertase; accordingly, mass spectrometry analysis indicates that sbt-1 activity is required for production of some neuropeptides; sbt-1 mutant animals are also aldicarb resistant, suggesting that SBT-1 is required for normal cholinergic signaling; in both in vitro and in vivo assays, SBT-1 facilitates maturation of vertebrate proPC2; sbt-1 promoter fusions are expressed in most neurons and in the pharynx; when expressed in DA cholinergic neurons under the control of the unc-129 promoter, SBT-1::YFP localizes to puncta adjacent to the synaptic vesicle reporter SNB-1::RFP.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12738
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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      Transgenic construct
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          sbt-1 molecule type
          Interactor gene
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            Genetic Interactions

            sbt-1 role
            sbt-1 genetic perturbation
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