Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule; regulation of microtubule polymerization or depolymerization; and spindle assembly. Located in cell cortex and microtubule cytoskeleton. Is expressed in neurons. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1); MAPRE2 (microtubule associated protein RP/EB family member 2); and MAPRE3 (microtubule associated protein RP/EB family member 3).
WB Description
ebp-1 encodes one of three C. elegans homologs of the EB1 family of microtubule plus-end binding proteins; a deletion mutation in ebp-1, tm1357, has been reported to result in sluggish locomotion and a weak egg-laying defective phenotype; in embryos, an EBP-1::GFP fusion protein localizes to the distal tip of microtubules and, during the cell cycle, moves from the centrosomes to the cell cortex.