Gene

ebp-1

Species
Caenorhabditis elegans
Symbol
ebp-1
Name
microtubule End Binding Protein 1
Synonyms
  • CELE_Y59A8B.7
  • Y59A8B.7
Biotype
protein coding gene
Automated Description
Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule; regulation of microtubule polymerization or depolymerization; and spindle assembly. Located in cell cortex and microtubule cytoskeleton. Is expressed in neurons. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1); MAPRE2 (microtubule associated protein RP/EB family member 2); and MAPRE3 (microtubule associated protein RP/EB family member 3).
WB Description
ebp-1 encodes one of three C. elegans homologs of the EB1 family of microtubule plus-end binding proteins; a deletion mutation in ebp-1, tm1357, has been reported to result in sluggish locomotion and a weak egg-laying defective phenotype; in embryos, an EBP-1::GFP fusion protein localizes to the distal tip of microtubules and, during the cell cycle, moves from the centrosomes to the cell cortex.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10623
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
18.044M18.045M18.046M18.047M18.048M18.049M18.050M18.051M18.052M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions