Version: 8.0.0
Date: Tue Jan 28 2025
ssu-1
Caenorhabditis elegansWB:WBGene00013748
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ssu-1

Species
Caenorhabditis elegans
Symbol
ssu-1
Name
Suppressor of Stomatin mutant Uncoordination 1
Synonyms
  • CELE_Y113G7A.11
  • ceST1
Biotype
protein coding gene
Automated Description
Enables aryl sulfotransferase activity. Involved in sulfur compound metabolic process. Located in cytosol. Is expressed in ASJL and ASJR. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital ichthyosis 14; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1A3 (sulfotransferase family 1A member 3).
WB Description
ssu-1 encodes, by alternative splicing, two isoforms of a cytosolicalcohol sulfotransferase that interacts in the ASJ amphid neurons with thestomatins UNC-1 and UNC-24; the longer SSU-1 isoform is required fornormal anesthetic sensitivity and unc-1 phenotypes; ssu-1(fc73) suppressesthe anesthetic sensitivity and uncoordinated phenotypes of unc-1 andunc-24 mutants; ssu-1(fc73), along with daf-12, suppresses the syntheticconstitutive dauer-formation phenotype of fc83;unc-24(e138) mutants; ssu-1suppression is rescued by transgenic expression of SSU-1 in the ASJneurons alone, implying that sulfation is required for an endocrinefunction; SSU-1 protein sulfates 4-nitrophenol and 2-naphthol substrates,and bisphenol A, but not monoamines or hydroxysteroids; SSU-1 iscytosolic, but its activity is not detectable in cytosolic extracts; ssu-1is strongly expressed in embryos, growing larvae, and dauer larvae; ssu-1expression is increased in daf-2; by homology with othersulfotransferases, SSU-1 may link sulfates to the alcohol group of smallmolecules as part of detoxification or signal transduction.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11783
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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      Allele Synonyms
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      Variant
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            20.1285M20.1290M20.1295M20.1300M20.1305M20.1310M20.1315M20.1320M20.1325M20.1330M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ssu-1 molecule type
            Interactor gene
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              Genetic Interactions

              ssu-1 role
              ssu-1 genetic perturbation
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