Version: 8.0.0
Date: Tue Jan 28 2025
nstp-5
Caenorhabditis elegansWB:WBGene00014139
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

nstp-5

Species
Caenorhabditis elegans
Symbol
nstp-5
Name
Nucleotide Sugar TransPorter family 5
Synonyms
  • CELE_ZK896.9
  • ZK896.9
Biotype
protein coding gene
Automated Description
Predicted to enable UDP-galactose transmembrane transporter activity. Predicted to be involved in UDP-galactose transmembrane transport. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIm. Orthologous to human SLC35A2 (solute carrier family 35 member A2).
WB Description
ZK896.9 encodes a Golgi apparatus transporter for UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine (UDP-GlcNAc), and UDP-N-acetylgalactosamine (UDP-GalNAc); ZK896.9 is orthologous to human SLC35A3 (OMIM:605632) and paralogous to C03H5.2 and SRF-3; ZK896.9 has no obvious function in RNAi assays, but this could reflect genetic redundancy with its paralogs; ZK896.9 activity has been experimentally confirmed by heterologous expression in budding yeast, Chinese hamster cells, and Giardia lamblia.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10231
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          nstp-5 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            nstp-5 role
            nstp-5 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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