Gene

doxa-1

Species
Caenorhabditis elegans
Symbol
doxa-1
Name
dual oxidase maturation factor 1
Synonyms
  • C06E1.3
  • CELE_C06E1.3
Biotype
protein coding gene
Automated Description
Predicted to be involved in protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in gonad; hypodermis; terminal bulb; and vulva. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Orthologous to human DUOXA1 (dual oxidase maturation factor 1) and DUOXA2 (dual oxidase maturation factor 2).
WB Description
Predicted to be involved in protein transport. Predicted to be located in membrane. Expressed in gonad; hypodermis; terminal bulb; and vulva. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Is an ortholog of human DUOXA1 (dual oxidase maturation factor 1) and DUOXA2 (dual oxidase maturation factor 2).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR31158
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensDUOXA27 of 9YesYes   
Homo sapiensDUOXA17 of 9YesYes   
Mus musculusDuoxa17 of 9YesYes   
Mus musculusDuoxa27 of 9YesYes   
Rattus norvegicusDuoxa17 of 9YesYes   
Rattus norvegicusDuoxa27 of 9YesYes   
Xenopus tropicalisduoxa17 of 9YesYes   
Danio rerioduox25 of 9YesYes   
Drosophila melanogastermol8 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
blistered
dumpy
sick
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
8.5815M8.5820M8.5825M8.5830M8.5835M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
tm5042allele
im21allele with one associated variant
point mutation
  • splice donor variant
Yes
im32allele with one associated variant
point mutation
  • splice acceptor variant
Yes
NC_003281.10:g.8581352A>Tvariant
SNP
  • intron variant
NC_003281.10:g.8583447C>Tvariant
SNP
  • 3 prime UTR variant
NC_003281.10:g.8582287T>Avariant
SNP
  • intron variant
NC_003281.10:g.8582618G>Avariant
NC_003281.10:g.8583513C>Tvariant
SNP
  • 3 prime UTR variant
NC_003281.10:g.8583676C>Tvariant
SNP
  • 3 prime UTR variant
NC_003281.10:g.8581524C>Tvariant
SNP
  • synonymous variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Caenorhabditis elegansldEx118
Yes
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
8.5815M8.5820M8.5825M8.5830M8.5835MC06E1.3.1 (doxa-1)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

2 interactor genes based on 5 annotations
doxa-1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
bli-3Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:23028364
protein
csnk-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:37099597
protein
csnk-1Caenorhabditis elegans
protein
  • experimental interaction detection
PMID:37099597
protein
csnk-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:37099597
protein
csnk-1Caenorhabditis elegans
protein
  • experimental interaction detection
PMID:37099597
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Genetic Interactions

No data available