Version: 8.0.0
Date: Tue Jan 28 2025
trxr-1
Caenorhabditis elegansWB:WBGene00015553
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

trxr-1

Species
Caenorhabditis elegans
Symbol
trxr-1
Name
ThioRedoXin Reductase 1
Synonyms
  • C06G3.7
  • CELE_C06G3.7
Biotype
protein coding gene
Automated Description
Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Involved in ecdysis, collagen and cuticulin-based cuticle. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including epithelial cell; intestine; nervous system; pharynx; and vulva. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to several human genes including TXNRD3 (thioredoxin reductase 3).
WB Description
trxr-1 encodes one of two C. elegans thioredoxin reductases homologous to the mammalian TrxR1 and TrxR2 isozymes; like its mammalian homologs, TRXR-1 has a TGA-encoded C-terminal penultimate selenocysteine (Sec) residue; labelling of C. elegans with selenium-75 demonstrates that TR-Se is the major naturally occurring selenoprotein in C. elegans, and computational analysis indicates that it is probably the only selenoprotein encoded by the genome; the 3'-untranslated region of this gene contains a selenocysteine insertion sequence that is functional in mammalian cell culture; loss of trxr-1 activity, together with that of gsr-1, results in molting defects characterized by a failure to remove old cuticle and reduced, disulfide groups in the cuticle that remain oxidized; TRXR-1 function in the cuticle is selenocysteine-dependent.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48105
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          trxr-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            trxr-1 role
            trxr-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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