Predicted to enable cholesterol binding activity. Predicted to be involved in SREBP signaling pathway. Located in endoplasmic reticulum membrane. Part of protein-containing complex. Is expressed in gonad. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18 and hereditary spastic paraplegia 62. Orthologous to human ERLIN1 (ER lipid raft associated 1) and ERLIN2 (ER lipid raft associated 2).
WB Description
erl-1 encodes a protein of the prohibitin family and is orthologous to the human Erlin proteins, Erlin1 (KEO4) and Erlin2 (SPFH2), which are components of lipid rafts; human erlins have been implicated in negatively regulating IP3 receptors and other proteins through the endoplasmic reticulum-associated degradation (ERAD) pathway; in elegans, loss of erl-1 did not cause any obvious phenotype, did not seem to modulate the IP3 receptor, ITR-1, or ITR-1 dependent processes, like brood size, embryogenesis, or defecation rate; erl-1 did not affect the response to ER stress or play an essential role in the ERAD pathway; erl-1 is detected in the cytoplasm of early embryos, and in the gonad of adult worms.