Gene

erl-1

Species
Caenorhabditis elegans
Symbol
erl-1
Name
ERLin (ER lipid raft associated protein) homolog 1
Synonyms
  • C42C1.15
  • CELE_C42C1.15
Biotype
protein coding gene
Automated Description
Predicted to enable cholesterol binding activity. Predicted to be involved in SREBP signaling pathway. Located in endoplasmic reticulum membrane. Part of protein-containing complex. Is expressed in gonad. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18 and hereditary spastic paraplegia 62. Orthologous to human ERLIN1 (ER lipid raft associated 1) and ERLIN2 (ER lipid raft associated 2).
WB Description
erl-1 encodes a protein of the prohibitin family and is orthologous to the human Erlin proteins, Erlin1 (KEO4) and Erlin2 (SPFH2), which are components of lipid rafts; human erlins have been implicated in negatively regulating IP3 receptors and other proteins through the endoplasmic reticulum-associated degradation (ERAD) pathway; in elegans, loss of erl-1 did not cause any obvious phenotype, did not seem to modulate the IP3 receptor, ITR-1, or ITR-1 dependent processes, like brood size, embryogenesis, or defecation rate; erl-1 did not affect the response to ER stress or play an essential role in the ERAD pathway; erl-1 is detected in the cytoplasm of early embryos, and in the gonad of adult worms.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15351
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
12.2880M12.2882M12.2884M12.2886M12.2888M12.2890M12.2892M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions