Gene

nep-4

Species
Caenorhabditis elegans
Symbol
nep-4
Name
NEPrilysin metallopeptidase family 4
Synonyms
  • C53B7.7
  • CELE_C53B7.7
Biotype
protein coding gene
Automated Description
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)) and ECEL1 (endothelin converting enzyme like 1).
WB Description
C53B7.7 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C53B7.7 has no clear orthologs in other organisms.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11733
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
6.8610M6.8612M6.8614M6.8616M6.8618M6.8620M6.8622M6.8624M6.8626M6.8628M6.8630M6.8632M6.8634M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions