Gene

maco-1

Species
Caenorhabditis elegans
Symbol
maco-1
Name
MACOilin homolog 1
Synonyms
  • CELE_D2092.5
  • D2092.5
Biotype
protein coding gene
Automated Description
Predicted to enable microtubule binding activity. Involved in chemotaxis; neuronal signal transduction; and thermotaxis. Located in neuronal cell body; nuclear envelope; and rough endoplasmic reticulum. Is expressed in epithelial cell; muscle cell; and nervous system. Orthologous to human MACO1 (macoilin 1).
WB Description
maco-1 encodes a novel protein with five transmembrane domains in the N-terminus and four coiled coil domains in the C-terminus; maco-1 is functionally conserved across species and is orthologous to human macoilin (OMIM:601301); macoilin is involved in assembly or traffic of ion channels or ion channel regulators; MACO-1 is not required for development but for appropriate regulation of neuronal activity; both transmembrane domains and coiled coil domains are required for appropriate function of MACO-1; proper function of MACO-1 is necessary for normal thermotaxis in many neurons; mutations in C. elegans macoilin disrupt aggregation and are associated with multiple behavioral defects; MACO-1 is localized to the rough ER of neurons; MACO-1 is also restricted to neuronal cell bodies at embryonic developmental stages.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13289
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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6.599M6.600M6.601M6.602M6.603M6.604M6.605M6.606M6.607M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions