Predicted to enable microtubule binding activity. Involved in chemotaxis; neuronal signal transduction; and thermotaxis. Located in neuronal cell body; nuclear envelope; and rough endoplasmic reticulum. Is expressed in epithelial cell; muscle cell; and nervous system. Orthologous to human MACO1 (macoilin 1).
WB Description
maco-1 encodes a novel protein with five transmembrane domains in the N-terminus and four coiled coil domains in the C-terminus; maco-1 is functionally conserved across species and is orthologous to human macoilin (OMIM:601301); macoilin is involved in assembly or traffic of ion channels or ion channel regulators; MACO-1 is not required for development but for appropriate regulation of neuronal activity; both transmembrane domains and coiled coil domains are required for appropriate function of MACO-1; proper function of MACO-1 is necessary for normal thermotaxis in many neurons; mutations in C. elegans macoilin disrupt aggregation and are associated with multiple behavioral defects; MACO-1 is localized to the rough ER of neurons; MACO-1 is also restricted to neuronal cell bodies at embryonic developmental stages.