Gene

csr-1

Species
Caenorhabditis elegans
Symbol
csr-1
Name
Chromosome-Segregation and RNAi deficient 1
Synonyms
  • CELE_F20D12.1
  • F20D12.1
Biotype
protein coding gene
Automated Description
Enables endoribonuclease activity, cleaving siRNA-paired mRNA. Involved in P granule assembly; mitotic sister chromatid segregation; and siRNA-mediated gene silencing by mRNA destabilization. Located in P granule; condensed nuclear chromosome; and metaphase plate. Is expressed in several structures, including germ line; somatic cell; sperm; spermatid; and spermatocyte.
WB Description
csr-1 encodes, by alternative splicing, two isoforms of an Argonaute protein required for chromosome segregation, embryonic viability, Slicer activity induced by secondary siRNAs, and (partially) for germline RNAi; csr-1(RNAi) embryos are generally inviable, with disordered metaphase chromosomes and anaphase DNA bridges; CSR-1 is found in secondary-type siRNA/Slicer complexes, and isolated recombinant CSR-1 itself shows Slicer activity with secondary-type siRNAs; csr-1(fj54) mutant cell-free extracts have only 10% the normal level of secondary siRNA-induced Slicer activity; csr-1 mutants are partially defective in germline RNAi; CSR-1 belongs to a nematode-specific group of Argonaute homologs, and is most closely related to C04F12.1; like ALG-1/2 and RDE-1, but unlike some other Argonaute homologs, CSR-1 retains key catalytic residues in an RNAse H domain.
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
7.9575M7.9580M7.9585M7.9590M7.9595M7.9600M7.9605M7.9610M7.9615M7.9620M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions