Version: 8.0.0
Date: Tue Jan 28 2025
csr-1
Caenorhabditis elegansWB:WBGene00017641
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

csr-1

Species
Caenorhabditis elegans
Symbol
csr-1
Name
Chromosome-Segregation and RNAi deficient 1
Synonyms
  • CELE_F20D12.1
  • F20D12.1
Biotype
protein coding gene
Automated Description
Enables endoribonuclease activity, cleaving siRNA-paired mRNA. Involved in P granule assembly; mitotic sister chromatid segregation; and siRNA-mediated gene silencing by mRNA destabilization. Located in P granule; condensed nuclear chromosome; and metaphase plate. Is expressed in several structures, including germ line; somatic cell; sperm; spermatid; and spermatocyte.
WB Description
csr-1 encodes, by alternative splicing, two isoforms of an Argonaute protein required for chromosome segregation, embryonic viability, Slicer activity induced by secondary siRNAs, and (partially) for germline RNAi; csr-1(RNAi) embryos are generally inviable, with disordered metaphase chromosomes and anaphase DNA bridges; CSR-1 is found in secondary-type siRNA/Slicer complexes, and isolated recombinant CSR-1 itself shows Slicer activity with secondary-type siRNAs; csr-1(fj54) mutant cell-free extracts have only 10% the normal level of secondary siRNA-induced Slicer activity; csr-1 mutants are partially defective in germline RNAi; CSR-1 belongs to a nematode-specific group of Argonaute homologs, and is most closely related to C04F12.1; like ALG-1/2 and RDE-1, but unlike some other Argonaute homologs, CSR-1 retains key catalytic residues in an RNAse H domain.
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          csr-1 molecule type
          Interactor gene
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            Genetic Interactions

            csr-1 role
            csr-1 genetic perturbation
            Interactor gene
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