Version: 8.0.0
Date: Tue Jan 28 2025
lim-8
Caenorhabditis elegansWB:WBGene00017904
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

lim-8

Species
Caenorhabditis elegans
Symbol
lim-8
Name
LIM domain family 8
Synonyms
  • CELE_F28F5.3
  • F28F5.3
Biotype
protein coding gene
Automated Description
Enables protein domain specific binding activity. Predicted to be involved in positive regulation of stress fiber assembly and regulation of focal adhesion assembly. Located in M band. Is expressed in several structures, including excretory canal; non-striated muscle; pharynx; spermatheca; and vulva. Orthologous to several human genes including LIMCH1 (LIM and calponin homology domains 1).
WB Description
lim-8 encodes proteins containing one PDZ and one LIM domain; in vitro binding and yeast two-hybrid assays indicate that LIM-8 can physically interact with myosin heavy chain A (MYO-3) as well as with UNC-96 and UNC-97, suggesting that LIM-8 is part of a structural component that links membrane attachment proteins to myosin thick filaments; lim-8(RNAi) in a hypersensitive rrf-3 background results in partially penetrant paralysis at mid-larval stages of development; a lim-8::gfp promoter fusion is expressed in pharyngeal and body wall muscles, as well as in vulva, spermathecae, anal sphincter and depressor muscles, head neurons, gonadal sheath, and the excretory canal; staining with LIM-8 antibodies reveals that in body wall muscle LIM-8 localizes, at least partially, to M-lines, around which myosin thick filaments are organized.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15551
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          lim-8 molecule type
          Interactor gene
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          Interactor molecule type
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            Genetic Interactions

            lim-8 role
            lim-8 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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