Version: 8.0.0
Date: Tue Jan 28 2025
odr-8
Caenorhabditis elegansWB:WBGene00018160
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

odr-8

Species
Caenorhabditis elegans
Symbol
odr-8
Name
ODoRant response abnormal 8
Synonyms
  • CELE_F38A5.1
  • F38A5.1
Biotype
protein coding gene
Automated Description
Enables deUFMylase activity. Involved in several processes, including positive regulation of chemotaxis; protein localization to non-motile cilium; and response to ethanol. Part of protein-containing complex. Is expressed in hypodermis; intestine; and nervous system. Used to study early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2).
WB Description
odr-8 encodes the C. elegans ortholog of Ufm1-specific protease 2 (UfSP2); ODR-8 activity is required cell-autonomously for localization of a subset of G protein-coupled receptors (GPCRs), including ODR-10, by a Ufm1-independent mechanism; in regulating receptor localization, ODR-8 appears to function at an early step in GPCR trafficking; consequently, odr-8 mutant animals display defects in odortaxis, aggregation behavior, and responses to oxygen; ODR-8 physically interacts with ODR-4 to form a complex at the endoplasmic reticulum membrane; odr-8 is expressed in twelve chemosensory neurons: the ten amphid neurons and two phasmid neurons; odr-8 expression overlaps that of odr-4.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48153
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          odr-8 molecule type
          Interactor gene
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            Genetic Interactions

            odr-8 role
            odr-8 genetic perturbation
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