Version: 8.0.0
Date: Tue Jan 28 2025
cyp-33E2
Caenorhabditis elegansWB:WBGene00018334
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

cyp-33E2

Species
Caenorhabditis elegans
Symbol
cyp-33E2
Name
CYtochrome P450 family 33E2
Synonyms
  • CELE_F42A9.5
  • F42A9.5
Biotype
protein coding gene
Automated Description
Enables monooxygenase activity. Involved in long-chain fatty acid metabolic process and regulation of nematode pharyngeal pumping. Located in intracellular membrane-bounded organelle. Is expressed in pharynx. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Orthologous to human CYP2C8 (cytochrome P450 family 2 subfamily C member 8).
WB Description
cyp-33E2 encodes a cytochrome P450; when co-expressed with human CPR in vitro, CYP-33E2 exhibits monooxygenase activity on a variety of long-chain fatty acid substrates, including eicosapentaenoic acid and arachidonic acid; cyp-33E2(RNAi) animals show reduced rates of pharyngeal pumping, suggesting that CYP-33E2-generated metabolites may play a role in regulating pharyngeal muscle contraction; a cyp-33E2::GFP reporter fusion is expressed in the pharynx, particularly in the pharyngeal marginal cells, throughout larval development and adulthood.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24300
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            8.6124M8.6126M8.6128M8.6130M8.6132M8.6134M8.6136M8.6138M8.6140M8.6142M8.6144M8.6146M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            cyp-33E2 molecule type
            Interactor gene
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              Genetic Interactions

              cyp-33E2 role
              cyp-33E2 genetic perturbation
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