Version: 8.0.0Date: Tue Jan 28 2025
Gene
lin-42
- Species
- Caenorhabditis elegans
- Symbol
- lin-42
- Name
- abnormal cell LINeage 42
- Synonyms
- Cel-Mir-10-P3e
- CELE_F47F6.1
- Biotype
- protein coding gene
- Automated Description
- Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of dauer larval development; negative regulation of miRNA transcription; and regulation of development, heterochronic. Located in cytoplasm and nucleus. Is expressed in several structures, including H1L.app; H1R.app; H2L.ppp; hypodermal cell; and pharynx. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome; advanced sleep phase syndrome 1; alcohol dependence; cocaine dependence; and fetal alcohol spectrum disorder. Orthologous to human PER1 (period circadian regulator 1) and PER2 (period circadian regulator 2).
- WB Description
- lin-42 encodes three PAS domain-containing proteins orthologous to insect and vertebrate Period proteins that function in regulation of circadian rhythms; during larval development, lin-42 functions in the heterochronic pathway to regulate developmental switches that occurs in multiple tissues, including the hypodermis, gonad, sex myoblasts, and vulva; genetic analysis suggests that, in the hypodermis, lin-42 acts downstream of lin-46 and in the hypodermis and gonad, in parallel to daf-12 and upstream of lin-29; lin-42 mRNA levels oscillate during larval development with peak levels seen during intermolts and low levels seen during ecdysis and after the L4-to-adult molt; LIN-42 protein appears to be a widely expressed nuclear protein whose levels also fluctuate during larval stages, with peak protein typically seen towards the latter half of each larval stage in a cell type-specific manner, and then disappearing during each successive molt; in addition to three PAS domain-containing proteins, lin-42 also encodes a protein that lacks the PAS domain; transformation rescue experiments indicate that the LIN-42 isoform lacking the PAS domain is sufficient for rescue when present in multiple copies.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11269
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrII:1233236...1252359 - (19.12 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.