Gene

asp-7

Species
Caenorhabditis elegans
Symbol
asp-7
Name
ASpartyl Protease 7
Synonyms
  • CELE_F59D6.2
  • F59D6.2
Biotype
protein coding gene
Automated Description
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1); BACE2 (beta-secretase 2); and PGC (progastricsin).
WB Description
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease and frontotemporal dementia. Is an ortholog of human BACE1 (beta-secretase 1); BACE2 (beta-secretase 2); and PGC (progastricsin).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13683
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensBACE12 of 9YesYes   
Homo sapiensBACE22 of 9YesYes   
Homo sapiensPGC2 of 9YesYes   
Mus musculusPgc2 of 9YesYes   
Rattus norvegicusPgc2 of 9YesYes   
Xenopus tropicalispgc.43 of 9YesNo   
Xenopus tropicalispgc.23 of 9YesNo   
Xenopus tropicalisbace22 of 9YesYes   
Xenopus tropicalisctse2 of 9YesYes   
Xenopus tropicalisbace12 of 9YesYes   
Drosophila melanogasterCG172832 of 9YesYes   
Saccharomyces cerevisiaeMKC73 of 9YesYes   
Saccharomyces cerevisiaePEP43 of 9YesNo   
Saccharomyces cerevisiaeYPS33 of 9YesYes   
Saccharomyces cerevisiaeBAR13 of 9YesYes   
Saccharomyces cerevisiaeYPS63 of 9YesYes   
Saccharomyces cerevisiaeYPS13 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
asp-8138687805 of 8  
asp-16239462414 of 8  
asp-1338862424 of 8  
asp-15439059404 of 8  
asp-18538657394 of 8  
asp-17639756374 of 8  
asp-12740052344 of 8  
asp-6840653353 of 8  
asp-5939851344 of 8  
hrg-71043648313 of 8  
asp-21142946313 of 8  
asp-41240344284 of 8  
asp-31340147303 of 8  
asp-91439548303 of 8  
asp-131539446283 of 8  
asp-141640244252 of 8  
asp-191724848314 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
3.0284M3.0286M3.0288M3.0290M3.0292M3.0294M3.0296M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_003283.11:g.3028892G>Avariant
SNP
  • missense variant
NC_003283.11:g.3029556A>Tvariant
SNP
  • synonymous variant
NC_003283.11:g.3029487G>Avariant
SNP
  • synonymous variant
NC_003283.11:g.3028584C>Avariant
SNP
  • missense variant
NC_003283.11:g.3029091G>Cvariant
SNP
  • missense variant
NC_003283.11:g.3029394C>Gvariant
SNP
  • synonymous variant
NC_003283.11:g.3028776G>Avariant
SNP
  • missense variant
NC_003283.11:g.3028646A>Gvariant
SNP
  • missense variant
NC_003283.11:g.3029101T>Cvariant
SNP
  • synonymous variant
NC_003283.11:g.3028630C>Tvariant
Showing 1 - 10 of 23 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
3.0284M3.0286M3.0288M3.0290M3.0292M3.0294M3.0296MF59D6.2.1 (asp-7)

Sequence Details

Transcript: Mode:
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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available