Version: 8.0.0
Date: Tue Jan 28 2025
crtc-1
Caenorhabditis elegansWB:WBGene00021237
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

crtc-1

Species
Caenorhabditis elegans
Symbol
crtc-1
Name
CREB-Regulated Transcription Coactivator homolog 1
Synonyms
  • CELE_Y20F4.2
  • Y20F4.2
Biotype
protein coding gene
Automated Description
Enables cAMP response element binding protein binding activity. Involved in determination of adult lifespan. Located in cytosol and nucleus. Is expressed in head neurons; intestine; and tail neurons. Orthologous to several human genes including CRTC1 (CREB regulated transcription coactivator 1).
WB Description
crtc-1 encodes a CREB-regulated transcriptional coactivator orthologous to mammalian CRTCs (OMIM: 608972); CRTC-1 is a central node linking the upstream lifespan modifiers AMPK and calcineurin to CREB activity via a shared signal-transduction pathway; posttranslational modification of CRTC-1 is required for their effects on longevity; CRTC-1 is both a critical and direct target of aak-2-mediated longevity; the longevity effects of inactivating crtc-1 are mediated by crh-1; crtc-1 is expressed throughout the intestine of the worm, as well as in head and tail neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13589
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          crtc-1 molecule type
          Interactor gene
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          Interactor molecule type
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            Genetic Interactions

            crtc-1 role
            crtc-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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