Version: 8.0.0
Date: Tue Jan 28 2025
mksr-2
Caenorhabditis elegansWB:WBGene00021416
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mksr-2

Species
Caenorhabditis elegans
Symbol
mksr-2
Name
MecKel Syndrome 1 (MKS1)-Related 2
Synonyms
  • CELE_Y38F2AL.2
  • tza-1
Biotype
protein coding gene
Automated Description
Involved in several processes, including determination of adult lifespan; larval foraging behavior; and non-motile cilium assembly. Located in ciliary basal body; ciliary transition zone; and dendrite terminus. Is expressed in neurons. Used to study Joubert syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to human B9D2 (B9 domain containing 2).
WB Description
mkrs-2 encodes an ortholog of human B9D2 (OMIM:611951), paralogous to MKRS-1 and MKS-1; MKRS-2 is required for fully normal foraging behavior, and is redundantly required with NPH-4 for roughly normal foraging, and with both NPH-1 and NPH-4 for cilia formation; MKRS-2 is expressed in most ciliated cells, including amphid, phasmid, and labial-quadrant neurons, in a DAF-19-dependent manner; MKRS-2 forms a complex with MKRS-1 and MKS-1 at the base of cilia, and is coexpressed with these proteins in ciliated sensory neurons; MKRS-2 protein is required for proper localization of MKRS-1 and MKS-1 to the transition zone, and binds MKRS-1 in two-hybrid assays.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12968
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          mksr-2 molecule type
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            Genetic Interactions

            mksr-2 role
            mksr-2 genetic perturbation
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