Version: 8.0.0
Date: Tue Jan 28 2025
gbb-1
Caenorhabditis elegansWB:WBGene00021528
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

gbb-1

Species
Caenorhabditis elegans
Symbol
gbb-1
Name
GABA B receptor subunit 1
Synonyms
  • CELE_Y41G9A.4
  • Y41G9A.4
Biotype
protein coding gene
Automated Description
Enables G protein-coupled GABA receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1).
WB Description
gbb-1 encodes, by alternative splicing, one isoform of a subunit of the GABAB receptor dimer (GBB-1/2); GBB-1 is orthologous to human GABBR1 (OMIM:603540); GBB-1/2 is required for inhibition of cholinergic motor neurons by GABA, and thus for normally restrained movement and aldicarb resistance; gbb-1(tm1406) mutants move abnormally fast, with abnormally few changes of direction.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10519
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          gbb-1 molecule type
          Interactor gene
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            Genetic Interactions

            gbb-1 role
            gbb-1 genetic perturbation
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