Version: 8.0.0
Date: Tue Jan 28 2025
mbtr-1
Caenorhabditis elegansWB:WBGene00021661
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mbtr-1

Species
Caenorhabditis elegans
Symbol
mbtr-1
Name
MBT (Malignant Brain Tumor) Repeat containing protein 1
Synonyms
  • CELE_Y48G1A.6
  • Y48G1A.6
Biotype
protein coding gene
Automated Description
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to several human genes including L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1).
WB Description
mbtr-1 encodes a protein with four malignant brain tumor (MBT) repeats; MBTR-1 is orthologous to Drosophila L(3)MBT and human L3MBTL (OMIM:608802) and SFMBT1 (RU1; OMIM:607319), and is paralogous to LIN-61; loss of mbtr-1 function via RNAi or mutation results in no obvious abnormalities; unlike lin-61, mbtr-1 does not appear to function as a class B synMuv gene or exhibit other pleiotropies, such as RNAi hypersensitivity or misregulation of transgene expression, associated with class B synMuv genes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12247
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          mbtr-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            mbtr-1 role
            mbtr-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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