Version: 8.0.0
Date: Tue Jan 28 2025
ZK1240.5
Caenorhabditis elegansWB:WBGene00022870
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ZK1240.5

Species
Caenorhabditis elegans
Symbol
ZK1240.5
Name
RING-type domain-containing protein
Synonyms
  • CELE_ZK1240.5
Biotype
protein coding gene
Automated Description
Predicted to enable zinc ion binding activity. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to several human genes including BSPRY (B-box and SPRY domain containing); MEFV (MEFV innate immunity regulator, pyrin); and RNF39 (ring finger protein 39).
WB Description
Predicted to enable zinc ion binding activity. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; and hematologic cancer (multiple). Is an ortholog of several human genes including MEFV (MEFV innate immunity regulator, pyrin); TRIM21 (tripartite motif containing 21); and TRIM27 (tripartite motif containing 27).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47156
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          ZK1240.5 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            ZK1240.5 role
            ZK1240.5 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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