Version: 8.0.0
Date: Tue Jan 28 2025
dyrk1a
Xenopus tropicalisXenbase:XB-GENE-1017105
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

dyrk1a

Species
Xenopus tropicalis
Symbol
dyrk1a
Name
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms
  • dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • dyrk1a
Biotype
gene
Automated Description
Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity; protein tyrosine kinase activity; and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription and positive regulation of RNA splicing. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in anatomical system; ectoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
XBXT Description
Dual-specificity tyrosine-phosphorylation regulated kinase
https://www.xenbase.org/gene/showgene.do?method=display&geneId=1017104
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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        Experimental condition
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          Sequence Feature Viewer

          Genome location
          Assembly version
          XT9.1
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          None
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          dyrk1a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            dyrk1a role
            dyrk1a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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