Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Predicted to be involved in negative regulation of smoothened signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in musculoskeletal system and nervous system. Human ortholog(s) of this gene implicated in basal cell carcinoma and medulloblastoma. Orthologous to human PTCH2 (patched 2).