Gene

stat4

Species
Xenopus tropicalis
Symbol
stat4
Name
signal transducer and activator of transcription 4
Synonyms
  • signal transducer and activator of transcription 4
  • stat4
Biotype
gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of transcription by RNA polymerase II; and response to peptide hormone. Predicted to act upstream of or within regulation of DNA-templated transcription and signal transduction. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); genital herpes; and scleroderma (multiple). Orthologous to human STAT4 (signal transducer and activator of transcription 4).
XBXT Description
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            XT9.1
            Viewer Help
            43.24M43.26M43.28M43.30M43.32M43.34M43.36M43.38M43.40M43.42M43.44M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            None
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            stat4 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              stat4 role
              stat4 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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