transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms
abc18
abcb3
Biotype
gene
Automated Description
Predicted to enable ABC-type oligopeptide transporter activity. Predicted to act upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I and transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of TAP complex. Human ortholog(s) of this gene implicated in several diseases, including aspirin-induced respiratory disease; autoimmune disease (multiple); cervical cancer (multiple); dengue hemorrhagic fever; and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member).