Gene

smad2

Species
Xenopus tropicalis
Symbol
smad2
Name
SMAD family member 2
Synonyms
  • SMAD family member 2
  • smad-2
Biotype
gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic body morphogenesis and gastrulation with mouth forming second. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 6; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2).
XBXT Description
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSMAD29 of 9YesYes   
Mus musculusSmad28 of 9YesYes   
Rattus norvegicusSmad28 of 9YesYes   
Xenopus laevissmad2.L1 of 1YesYes           
Xenopus laevissmad2.S1 of 1YesYes           
Danio reriosmad29 of 9YesYes   
Drosophila melanogasterSmox6 of 9YesYes   
Caenorhabditis eleganssma-24 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
smad7146242272 of 8  
cdk627742285 of 8  
tmem5433241316 of 8  
smad146 of 8  
smad946 of 8  
smad355 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal axis elongation
abnormal bending of tail
abnormal development of embryo
abnormal gastrulation
abnormal tail morphology
decreased length of anterior-posterior axis
decreased length of tail
decreased size of the tail
Showing 1 - 8 of 8 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
XT9.1
Viewer Help
192.635M192.640M192.645M192.650M192.655M192.660M192.665MNM_001011168.1 (smad2)XM_012960839.2 (smad2)XM_012960846.2 (smad2)XM_012960854.2 (smad2)XM_012960860.2 (smad2)XM_018092812.1 (smad2)XM_018092813.1 (smad2)XM_018092817.1 (smad2)XT-9_1-rna18282 (smad2)XT-9_1-rna18283 (smad2)Maximum features displayed. See full view for more.

Sequence Details

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Expression

Primary Sources
Other Sources
None
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available